Description
Gonadorelin is the synthetic form of gonadotropin-releasing hormone (GnRH), a naturally occurring hypothalamic decapeptide that regulates reproduction by stimulating the pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Clinically, gonadorelin has been used for diagnostic testing of pituitary function and, in certain contexts, to support ovulation/infertility treatment when hypothalamic GnRH secretion is insufficient.
Molecular Formula: C₅₅H₇₅N₁₇O₁₃
Molecular Weight: ~1182.3 g/mol
CAS Number: 33515-09-2
What Are the Effects of Gonadorelin?
Gonadorelin is recognized for several key effects:
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LH and FSH Release: Promotes pituitary secretion of LH and FSH after GnRH receptor activation.
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Evaluation of Hypothalamic–Pituitary Function (Diagnostic Use): Used to assess pituitary gonadotrope responsiveness in suspected dysfunction.
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Reproductive Axis Activation: By increasing LH/FSH, it can influence downstream gonadal steroidogenesis and ovulatory function in appropriate medical contexts.
How Does It Work?
Gonadorelin binds to the GnRH receptor on anterior pituitary gonadotroph cells, triggering intracellular signaling that leads to synthesis and release of LH and FSH. A key physiological concept is that the frequency of GnRH pulses can shift pituitary output (faster pulses favor LH, slower pulses favor FSH), which is why pulsatile delivery has been used in certain infertility protocols.
Scientific Evidence and Research Status
Unlike many “research peptides,” gonadorelin is a long-studied endocrine agent with medical/diagnostic use in humans, and it appears in multiple drug references and product monographs. However, its application depends heavily on the clinical scenario (diagnostic testing vs. ovulation induction in hypothalamic causes), and protocols vary by country and product.
Role in Sports and Performance Contexts
Because gonadorelin can stimulate the reproductive hormone axis, anti-doping rules address it directly. The WADA Prohibited List includes “gonadotrophin-releasing hormone (GnRH, gonadorelin) and its agonist analogues” as prohibited testosterone-stimulating peptides in males.
Dosage Guidelines
Gonadorelin dosing is best presented as published clinical ranges (not a universal “one-size-fits-all” guideline):
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Diagnostic pituitary testing (single-dose): commonly reported at ~100 micrograms (mcg) as a single dose.
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“More refined” endocrine studies: doses reported in the range of ~25 to 500 mcg daily in certain protocols.
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Pulsatile infertility protocols (specialized use): examples include ~5 mcg every 90 minutes delivered by a pump in some referenced guidance.
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High-dose exposure (safety context): an SmPC notes administration up to 3 mg twice daily for 28 days without signs of overdosage (this describes observed tolerance in that document, not routine practice).
Storage Instructions
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4℃ (39℉) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80℃ (-112℉). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
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