Description

Semax is a synthetic heptapeptide (7 amino acids) derived from an ACTH fragment and modified with a Pro-Gly-Pro sequence to improve stability while lacking the classic hormonal (adrenocorticotropic) activity of full ACTH. It has been used in Russia in neurological contexts (e.g., stroke), and it is also widely discussed as a “nootropic” research peptide.

Molecular Formula: C₃₇H₅₁N₉O₁₀S
Molecular Weight: ~813.9 g/mol
CAS Number: 80714-61-0

What Are the Effects of Semax?

Semax is associated with several research-discussed effects:

Neuroprotective / Neurotrophic Interest: Studied in models of brain injury and ischemia, and described as neuroprotective in some clinical traditions.
Cognitive / Attention Effects (Limited Human Data): Pilot and summarized reports describe changes in brain network activity and potential improvements in attention/short-term memory in certain settings.
Neurotrophin Signaling Interest (BDNF/NGF): Preclinical work reports increases in BDNF (and sometimes NGF) after administration in animal models.

How Does It Work?

Semax’s exact mechanism is not fully agreed upon, but literature summaries suggest it may modulate monoaminergic signaling and influence neurotrophin-related pathways (notably BDNF) in the brain. The Pro-Gly-Pro modification is discussed as improving the duration of effects in animal models compared with earlier ACTH fragments.

Scientific Evidence and Research Status

Semax has a notable research history and is used in Russia for some neurological indications, but well-conducted, widely accessible human trials in the international literature are limited, and many publications are in Russian or available only as abstracts. As a result, the strength of evidence for broad cognitive or “longevity” claims remains uncertain.

Role in Sports and Performance Contexts

In performance/nootropic circles, Semax is discussed for calm focus and cognition. For competitive sport, the safest approach is always to verify any compound against the current WADA Prohibited List and official medication-check tools, since rules are category-based and updated annually. (Semax is not typically listed by name in the way classic anabolic agents are, so status can depend on interpretation and context.)

Standard Dosage

Typical range spans 300-600 mcg daily, divided into 2-3 doses (e.g., 200-300 mcg AM, 100-200 mcg later), for cycles of 10-14 days on followed by 2-3 days off. This supports general cognitive research without rapid desensitization.

Storage Instructions

All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months.
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4℃ (39℉) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80℃ (-112℉). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.