Description
Hexarelin (also known as examorelin) is a synthetic hexapeptide classified as a growth hormone secretagogue (GHS). It was developed in endocrine research to stimulate endogenous growth hormone (GH) release, mainly by activating the ghrelin receptor (GHS-R1a).
Molecular Formula: C₄₇H₅₈N₁₂O₆
Molecular Weight: ~887.0 g/mol
CAS Number: 140703-51-1
What Are the Effects of Hexarelin?
Hexarelin is recognized for several key effects:
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Increased Growth Hormone Secretion: Produces a clear GH release response in controlled human studies.
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Endocrine Axis Effects Beyond GH (in some studies): Reports include stimulation of ACTH/cortisol and prolactin in certain contexts (e.g., during sleep studies).
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Appetite/Behavioral Interest (Pathway-Related): Because it acts through GHS-R1a (the ghrelin system), it is often discussed within broader ghrelin-related physiology.
How Does It Work?
Hexarelin works primarily by activating GHS-R1a (ghrelin receptor) on pituitary/hypothalamic pathways, triggering intracellular signaling that leads to pulsatile GH secretion. In controlled endocrine research, GH responses to hexarelin have been shown to be robust, and its activity is studied as part of the wider ghrelin/GHS system.
Scientific Evidence and Research Status
Hexarelin has been evaluated in human experimental studies, including placebo-controlled dose-escalation work assessing GH release in healthy volunteers.
However, it is not broadly established as a standardized long-term therapy in routine clinical practice across most countries, and the balance of benefits vs. risks outside controlled medical settings remains a key limitation.
Role in Sports and Performance Contexts
Hexarelin is specifically addressed in anti-doping rules: the WADA Prohibited List includes GH-releasing peptides (GHRPs) and explicitly lists examorelin (hexarelin) as an example.
Standard Dosage
Most protocols recommend 100 mcg per dose, 2-3 times daily (morning, post-workout, bedtime), totaling 200-300 mcg per day. Space doses evenly due to its short half-life of about 55 minutes.
These values reflect specific experimental protocols and do not define a standardized general-use dosage.
Storage Instructions
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4℃ (39℉) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80℃ (-112℉). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
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