Description
Selank is a synthetic heptapeptide (sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed as an analogue of the naturally occurring immunomodulatory peptide tuftsin. It has been studied mainly for potential anxiolytic (anti-anxiety) and neuromodulatory effects, with additional interest in immune-related signaling in preclinical research.
Molecular Formula: C₃₃H₅₇N₁₁O₉
Molecular Weight: ~751.87 g/mol
CAS Number: 129954-34-3
What Are the Effects of Selank?
Selank is recognized for several key effects (primarily based on preclinical evidence):
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Anxiolytic/Calming Effects: Studied for reducing anxiety-like behavior in animal models.
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Cognitive/Stress-Response Interest: Investigated for potential effects on stress-related behavior and neurochemical balance.
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Immune/Inflammation Signaling Interest: Research suggests it can influence expression of genes involved in inflammation and immune responses.
How Does It Work?
Selank is described as a neuromodulatory and immunomodulatory peptide rather than a single-target hormone. Preclinical studies suggest it may influence neurotransmitter-related pathways and gene expression patterns involved in stress and inflammatory signaling. Because the bulk of mechanistic detail comes from animal and molecular studies, the precise translation to consistent human clinical effects remains uncertain.
Scientific Evidence and Research Status
Most of the strong evidence for Selank comes from animal studies and molecular research. Peer-reviewed work documents behavioral and biological effects in rodents under various stress paradigms and experimental conditions, but robust large-scale human clinical trial evidence is limited compared with approved psychiatric medications.
Role in Sports and Performance Contexts
In performance and “nootropic” communities, Selank is discussed mainly for calm/focus and stress management. However, as with many experimental peptides, effects, purity, and safety can vary widely outside controlled settings.
For competitive athletes, the safest approach is to verify any substance against the current WADA Prohibited List (updated yearly) and consult medical/anti-doping support when needed.
Standard Dosage
Administer 400-500 mcg subcutaneously once daily, or 600-900 mcg intranasally split into 2-3 doses (e.g., 300 mcg morning and afternoon). Cycle 2-4 weeks on followed by equivalent time off.
These figures reflect research dosing in animals and do not establish a standardized human dose.
Storage Instructions
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4℃ (39℉) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80℃ (-112℉). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
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