Description
SNAP-8, scientifically termed Acetyl Octapeptide-3, is a synthetic cosmetic peptide developed as a “botox-like” topical ingredient. It is designed to help reduce the appearance of expression lines by modulating neurotransmitter-related signaling involved in facial muscle contraction, through mechanisms related to the SNARE complex / SNAP-25 pathway.
Molecular Formula: commonly listed as C41H70N16O16S (some datasheets list slightly different formulas depending on form/salt/hydration).
Molecular Weight: ~1075.16–1075.17 g/mol (can vary slightly by reference/form).
CAS Number: 868844-74-0
What Are the Effects of SNAP-8?
SNAP-8 is recognized for several key functions (mainly in cosmetic contexts):
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Reduction in the appearance of expression wrinkles: reported improvements in wrinkle depth/appearance in cosmetic studies.
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“Muscle-relaxing” cosmetic effect (indirect): aims to reduce micro-contractions that contribute to dynamic lines (forehead, crow’s feet).
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Skin-smoothing / anti-aging positioning: often formulated in serums/creams and anti-wrinkle patches.
How Does It Work?
SNAP-8 is described as an acetylcholine-release inhibiting peptide in cosmetic science discussions. It is conceptually related to peptides like acetyl hexapeptide-3 (Argireline®), which are designed to interfere with SNARE complex assembly (involving proteins such as SNAP-25) and thereby reduce neurotransmitter exocytosis associated with muscle contraction.
Scientific Evidence and Research Status
SNAP-8 is mainly positioned as a cosmetic active rather than a therapeutic drug. Reviews in cosmetic dermatology literature discuss it among “botox-like” peptides and report cosmetic study outcomes (e.g., reductions in wrinkle depth over several weeks of topical use), but the overall evidence base is more typical of cosmetic research than large-scale medical trials.
Role in Sports and Performance Contexts
SNAP-8 is not typically associated with sports performance enhancement. Its use is primarily aesthetic/cosmetic (skin appearance). For competitive athletes, general caution still applies with any compounded or injectable products, but SNAP-8 is most commonly encountered in topical formulations.
Standard Protocol
Apply 3-5% SNAP-8 products twice daily after cleansing, allowing 4-8 weeks for visible wrinkle reduction up to 30-60%. Mix reconstituted 10mg vials into 1 ounce of neutral cream or serum for custom use.
(These are formulation ranges reported in cosmetic contexts, not medical dosing standards.)
Storage Instructions
Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you’re ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4℃ (39℉) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.However, for longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80℃ (-112℉). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide’s stability.
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